Effect of Dextran Derivatives on Arginine Amidase Activities Released from Isolated Rabbit Arteries

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概要

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• In the present research we examined the levels and types of arginine amidase activities that were released from isolated rabbit arteries treated with heparin or chondroitin sulfate. Heparin accelerated the release of arginine amidase activity from the isolated rabbit ear artery, the induction was not significant; a slight increase in activity was observed in the level of arginine amidase released from isolated rabbit aorta, but no significant difference was observed. On the other hand, it was revealed that the addition of chondroitin sulfate, accelerated this release from isolated rabbit ear artery with 5% significant differences.After the addition of chondroitin sulfate, the arginine amidase activity released from isolated rabbit arteries was analyzed using various affinity adsorption methods. This analysis confirmed the presence of two types of fibrinolytic enzymes : plasminogen/plasmin activity and plasminogen activators, but no thrombin was detected.

• 公益社団法人日本薬学会の論文
• 1999-11-15

著者

• TAKEUCHI Koichi

  Departments of Clinical Pharmacology, Meiji Pharmaceutical University

• MIYAZAKI Kyousuke

  Seikagaku Kogyo Co.

• KATAYAMA Masatoki

  Functional Bioanalysis, Meiji Pharmaceutical University

• MATSUDA Yoshifumi

  Functional Bioanalysis, Meiji Pharmaceutical University

• Ishii-nozawa Reiko

  Department Of Clinical Pharmacology Meiji Pharmaceutical University

• Matsuda Y

  Department Of Functional Bioanalysis Meiji Pharmaceutical University

• Takeuchi Koichi

  Department Of Anatomy

• Takeuchi K

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Katayama M

  Department Of Functional Bioanalysis Meiji Pharmaceutical University

• Miyazaki K

  Seikagaku Kogyo Co.

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