Effects of Gangliosides, Ouabain and Arachidonic Acid on Glutamate Cytotoxicity in PC12 Cells
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概要
- 論文の詳細を見る
The present work shows that gangliosides prevent glutamate cytotoxicity in PC12 cells. Similarly, ouabain (1 and 5 μg/ml) protected cells against glutamate-induced toxicity in a dose-dependent manner. The cytoprotection observed with ouabain was not maintained after its association with gangliosides and glutamate. Also, the effects of gangliosides in blocking glutamate cytotoxicity did not persist in the presence of arachidonic acid. The results indicate that a higher degree of sodium pump inhibition is necessary for ouabain cytotoxicity to be manifested, and that a partial enzyme inhibition may actually be protective to glutamate and/or arachidonic acid-induced toxicity in PC12 cells.
- 公益社団法人日本薬学会の論文
- 1997-02-15
著者
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Cunha Geanne
Department Of Physiology And Pharmacology Faculty Of Medicine Federal University Of Ceara
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Cunha Geanne
Department Of Physiology And Pharmacology Federal University Of Ceara
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Moraes Manoel
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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Viana Glauce
Department Of Physiology And Pharmacology Faculty Of Medicine And Laboratory Of Natural Products Fed
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Viana Glauce
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceara
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Lyra Katarina
Department Of Physiology And Pharmacology Federal University Of Ceara
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Moraes Manoel
Department Of Physiology And Pharmacology Federal University Of Ceara
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PARAIBA Diane
Department of Physiology and Pharmacology, Federal University of Ceara
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Paraiba Diane
Department Of Physiology And Pharmacology Federal University Of Ceara
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