Demonstration of Inhibitory Effect of Oral Shark Cartilage on Basic Fibroblast Growth Factor-Induced Angiogenesis in the Rabbit Cornea
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概要
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Several angiogenic inhibitors have been obtained from shark cartilage, some of these are currently in clinical trials for assessment of safety and therapeutic efficacy in humans. Still, shark cartilage taken orally is commonly used in alternative and complimentary medicine for various silments including serious diseases such as cancer. However, only few studies of oral shark cartilage have demonstrated pharmacological effects in experimental animals or patients, to indicate safe doses with sufficient bioavailability. In the present study we demonstrated the antiangiogenic properties of oral shark cartilage in the rabbit cornea model. Slow-release, polymethylmetacrylate pellets containing basic fibroblast growth factor (bFGF) were surgically implanted in the rabbit cornea to stimulate neovascularization scored by stereo microscopy. Powdered shark cartilage (PSC;commercial product) was tested orally along with a water-soluble fraction (WSF) of this cartilage product which was tested by local application. Animals were treated with oral dosages of 100mg/kg PSC or 200mg/kg thalidomide as positive control. Pellets containing WAF (50, 100 or 200μg/pellet) or bFGF-inhibitor pentosan polysulfate were implanted adjacent to the bFGF pellet. Oral shark cartilage inhibited bFGF-induced angiogenesis, as didoral thalidomide, in this in vivo model. WSF and pentosan polysulfate was shown to block neovascularization in the cornea when applied locally. This study demonstrates that in the rabbit, oral shark cartilage appears to produce systemic levels of angiogenesis inhibitors that can exert their effect at the cornea.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
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PESSOA Claudia
Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara
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Pessoa Claudia
Department Of Physiology And Pharmacology School Of Medicine Federal University Of Ceara
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Pessoa Claudia
Department Of Physiology And Pharmacology Federal University Of Ceara
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Moraes M
Laboratory Of Experimental Oncology Department Of Physiology And Pharmacology Federal University Of
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Moraes Manoel
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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BARROS VIANA
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara
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Barros Viana
Department Of Physiology And Pharmacology Faculty Of Medicine Federal University Of Ceara
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Barros Viana
Department Of Physiology And Pharmacology Federal University Of Ceara
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Pessoa Claudia
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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GONZALEZ Raimundo
Department of Physiology and Pharmacology, Federal University of Ceara
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SOARES Felipe
Department of Physiology and Pharmacology, Federal University of Ceara
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FARIAS Romulo
Department of Physiology and Pharmacology, Federal University of Ceara
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LEYVA Albert
School of Pharmacy, University of Missouki-Kansas City
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Leyva Albert
School Of Pharmacy University Of Missouri-kansas City
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Soares Felipe
Department Of Physiology And Pharmacology Federal University Of Ceara
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Farias Romulo
Department Of Physiology And Pharmacology Federal University Of Ceara
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Gonzalez Raimundo
Laboratory Of Experimental Oncology Department Of Physiology And Pharmacology Federal University Of
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