Antitumor Activity of Biflorin, an o-Naphthoquinone Isolated from Capraria biflora(Pharmacology)
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概要
- 論文の詳細を見る
Pharmacological studies with an aqueous extract obtained from leaves of Capmria biflora showed potent cytotoxic, analgesic, antimicrobial and anti-inflammatory activities. It has been demonstrated that biflorin possesses an in vitro cytotoxic activity against tumor cells. The in vivo antitumor activity of biflorin was evaluated on two mouse models, sarcoma 180 and Ehrlich carcinoma. Biflorin was active against both tumors with a very similar profile. In addition, biflorin was also able to increase the response elicited by 5-FU in mice inoculated with both tumors. The results showed a decrease in Ki67 staining in tumor cells from treated-animals when compared with non-treated groups, which suggests an inhibition of tumor proliferation rate. Histopathological analysis from kidneys and liver showed that biflorin possessed weak and reversible toxic effects. It was also demonstrated that biflorin acts as an immunoadjuvant agent, rising the production of ovalbumin-specific antibodies and inducing a discreet increase of the white pulp and nest of megakaryocytic in spleen of treated mice, which can be related to its antitumor properties.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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BEZERRA Daniel
Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara
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ALVES Ana
Department of Clinical Odontology, Federal University of Ceara
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PESSOA Claudia
Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara
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COSTA-LOTUFO Leticia
Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara
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Pessoa Claudia
Department Of Physiology And Pharmacology School Of Medicine Federal University Of Ceara
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Pessoa Otilia
Departamento De Quimica Orgdnica E Inorgdnica Universidade Federal Do Ceard:centra De Ciencias Da Sa
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Pessoa Claudia
Department Of Physiology And Pharmacology Federal University Of Ceara
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Pessoa Otilia
Departamento De Farmacia Faculdade De Farmacia Odontologia E Enfermagem Universidade Federal Do Cear
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Moraes Manoel
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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Vasconcellos Marne
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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De Vasconcellos
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceara
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Alves Ana
Department Of Clinical Odontology Federal University Of Ceara
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Bezerra Daniel
Department Of Physiology And Pharmacology School Of Medicine Federal University Of Ceara
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Pereira Marcio
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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Pessoa Claudia
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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Fonseca Aluisio
Departamento De Quimica Orgdnica E Inorgdnica Universidade Federal Do Ceard
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LEMOS Telma
Departamento de Quimica Orgdnica e Inorgdnica, Universidade Federal do Ceard
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Lemos Telma
Departamento De Quimica Orgdnica E Inorgdnica Universidade Federal Do Ceard
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Lemos Telma
Departamento De Quimica Orgdnica E Inorgdnica Campus Do Pici
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Costa-lotufo Leticia
Department Of Physiology And Pharmacology School Of Medicine Federal University Of Ceara
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Costa-lotufo Leticia
Department Of Physiology And Pharmacology Federal University Of Ceara
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Costa-lotufo Leticia
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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