Analgesic, Antfiinflammatory and Central Depressor Effects of the Hydroalcoholic Extract and Fractions from Aeolanthus suaveolens(Pharmacology)
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概要
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This work studied antinociceptive, antiedematogenic and central depressor effects of the hydroalcoholic extract (HAE) from Aeolanthus suaveolens and its fractions: hexane (ASHAE-H), ethyl acetate (ASHAE-A), aqueous (ASHAE-E) and precipitate (ASHAE-PPT) in experimental models in mice. The highest activity in the writhing test was presented by ASHAE-A followed by ASHAE-PPT and ASHAE-E and the lowest by ASHAE-H. In the formalin test the effect was manifested at both phases, although more intensely at the 2nd phase of the response. In this test, the most active fraction was ASHAE-PPT causing inhibitions of the order of 76 and 90% of the 2nd phase of the test at the doses of 10 and 100mg/kg i.p., respectively. Naloxone reversed the effects of ASHAE-PPT in both phases of the test, suggesting the participation of the opioid system in the antinociceptive effect. On the other hand, the HAE effect on both phases of the formalin test was only partially reversed by naloxone, suggesting that the extract presents more than one active compound, and at least one, of a polar nature, acting through the opioid system. HAE and ASHAE-PPT presented antiinflammatory activity and were very effective in decreasing the mouse paw edema induced by carrageenan. All fractions significantly decreased locomotor activity in the open field test in mice. However, only the nonpolar fractions presented myorelaxant activity as demonstrated by the rota rod test.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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COSTA-LOTUFO Leticia
Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara
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SOUSA Francisca
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara
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Sousa Francisca
Department Of Physiology And Pharmacology Faculty Of Medicine Federal University Of Ceara
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Lucena David
Department Of Physiology And Pharmacology Federal University Of Ceara
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Viana Glauce
Department Of Physiology And Pharmacology Faculty Of Medicine And Laboratory Of Natural Products Fed
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Viana Glauce
Department Of Physiology And Pharmacology Federal University Of Ceara
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Viana Glauce
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceara
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Andrade-neto Manoel
Departamento De Quimica Orgdnica E Inorgdnica Universidade Federal Do Ceard
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Andrade-neto Manoel
Department Of Organic And Inorganic Chemistry Federal University Of Ceara
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Bezerra Jose
Department Of Organic And Inorganic Chemistry Federal University Of Ceara
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LEAL Luzia
Department of Physiology and Pharmacology, Federal University of Ceara
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Costa-lotufo Leticia
Department Of Physiology And Pharmacology School Of Medicine Federal University Of Ceara
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Leal Luzia
Departamento De Farmacia Faculdade De Farmacia Odontologia E Enfermagem Universidade Federal Do Cear
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Costa-lotufo Leticia
Department Of Physiology And Pharmacology Federal University Of Ceara
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Costa-lotufo Leticia
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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SOUSA Francisca
Department of Physiology and Pharmacology, Federal University of Ceara
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de Lucena
Department of Physiology and Pharmacology, Federal University of Ceara
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