Antidiabetic Activity of Bauhinia forficata Extracts in Alloxan-Diabetic Rats(Pharmacology)
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概要
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The antidiabetic activity of aqueous, ethanolic and hexanic extracts of Bauhiniaforficata was investigated in a model of alloxan-induced diabetes in rats. The biochemical parameters studied were: plasma glucose, serum triglycerides, cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). Extracts were administered daily for 7d at doses of 200 and 400 mg/kg, p.o., 48h after alloxan injection (60mg/kg, i.v.). The alloxan-diabetic rats showed significant reductions in plasma glucose, triglycerides, total cholesterol and HDL-cholesterol after treatment with the extracts and glibenclamide (used as standard) as compared to the diabetic controls. Levels of LDL were not altered. In conclusion, our results showed that the plant extracts when administered by gavage may reduce glucose, triglycerides, total cholesterol and HDL-cholesterol levels. These results suggest the validity of the clinical use ofB.forficata in the treatment of diabetes mellitus type II.
- 公益社団法人日本薬学会の論文
- 2004-01-01
著者
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Lino Cleide
Department Of Physiology And Pharmacology Federal University Of Ceard
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De Sousa
ブラジル
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De Sousa
Department Of Physiology And Pharmacology Faculty Of Medicine Federal University Of Ceara
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De Queiroz
Department of Biological Sciences, University of Essex, UK
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De Queiroz
Department Of Biological Sciences University Of Essex Uk
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Pereira Bruno
Department Of Physiology And Pharmacology Federal University Of Ceard
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Diogenes Joao
Department Of Physiology And Pharmacology Federal University Of Ceard
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Viana Glauce
Department Of Physiology And Pharmacology Faculty Of Medicine And Laboratory Of Natural Products Fed
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Viana Glauce
Department Of Physiology And Pharmacology Federal University Of Ceard
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Viana Glauce
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceara
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De Sousa
Departament Of Physiology Federal University Of Sergipe
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FARIA Rozilaine
Department of Organic Chemistry, Federal University of Ceard
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ANDRADE NETO
Department of Organic Chemistry, Federal University of Ceard
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ALVES Renata
Department of Pharmacy, Federal University of Ceard
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Andrade Neto
Department Of Organic Chemistry Federal University Of Ceard
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Alves Renata
Department Of Pharmacy Federal University Of Ceard
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Faria Rozilaine
Department Of Organic Chemistry Federal University Of Ceard
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