Antioxidant Effects in the Quinone Fraction from Auxemma oncocalyx TAUB

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概要

• 論文の詳細を見る

• In previous studies in vitro we showed that the quinone fraction (QF) from the heartwood of Auxemma oncoalyx TAUB. Presented antiplatelet and antioxidant activities. In the present work, the QF antioxidant property was evaluated in models of CCl_4-induced hepatotoxicity in rats, and prolongation of pentobarbital-induced sleeping time in mice. Our results showed that levels of plasma glutamate-pyruvate-transaminase (GPT), as well as glutamate-oxalate-transaminase (GOT), were increased by the administration of CCl_4. On the other hand, only GPT levels were reduced by the QF treatment. Pentobarbital sleeping time was prolonged by the administration of CCI_4 and reduced by the QF treatment. Moreover, QF did not alter the pentobarbital-induced sleeping time. In conclusion, we showed that QF, represented mainly by oncocalyxone A, has hepatoprotective activity, and this effect is at least in part due to the antioxidant activity of this quinone.

• 公益社団法人日本薬学会の論文
• 2003-05-01

著者

• Pessoa Otilia

  Departamento De Farmacia Faculdade De Farmacia Odontologia E Enfermagem Universidade Federal Do Cear

• Nunes Osmar

  Departamento De Farmacia Faculdade De Farmacia Odontologia E Enfermagem Universidade Federal Do Cear

• Viana Glauce

  Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceara

• Lemos Telma

  Departamento De Quimica Orgdnica E Inorgdnica Campus Do Pici

• Leal Luzia

  Departamento De Farmacia Faculdade De Farmacia Odontologia E Enfermagem Universidade Federal Do Cear

• Ferreira Maria

  Departamento De Farmacia Faculdade De Farmacia Odontologia E Enfermagem Universidade Federal Do Cear

• Leal Luiza

  Departamento de Farmacia, Faculdade de Farmacia, Odontologia e Enfermagem, Universidade Federal do Ceara

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