Production of an Antiproliferative Furanoheliangolide by Lychnophora ericoides Cell Culture
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概要
- 論文の詳細を見る
This work reports for the first time the production a furanoheliangolide (goyazensolide) by plant cell culture. Monitoring of the goyazensolide metabolism revealed that the maximum production occurred during the lag phase of the Lychnophora ericoides callus culture. The antiproliferative activity of obtained goyazensolide was evaluated against seven cancer cell lines using MTT assay. The results revealed a potent cytotoxic activity for the furaheliangolide with IC_<50> values in the range of 0.06μg/ml for CEM leukemia cells to 0.75μg/ml for B16 melanome cells.
- 公益社団法人日本薬学会の論文
- 2004-12-01
著者
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Lopes Norberto
Faculdade De Ciencias Farmaceuticas De Ribeirao Preto Universidade De Sao Paulo
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Pessoa Claudia
Department Of Physiology And Pharmacology School Of Medicine Federal University Of Ceara
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Pessoa Claudia
Department Of Physiology And Pharmacology Federal University Of Ceara
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Moraes Manoel
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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Pereira Ana
Department Of Vegetal Biotechnology University Of Ribeirdo Preto
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SANTOS Pierre
Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo
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Pereira Marcio
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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Amarante Maria
Faculdade De Ciencias Farmaceuticas De Ribeirao Preto Universidade De Sao Paulo:departamento De Biot
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Santos Pierre
Faculdade De Ciencias Farmaceuticas De Ribeirao Preto Universidade De Sao Paulo
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Pessoa Claudia
Departamento De Fisiologia E Farmacologia Faculdade De Medicina Universidade Federal Do Ceard
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BERTONI Bianca
Departamento de Biotecnologia Vegetal, Universidade de Ribeirao Preto
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FRANCA Suzelei
Departamento de Biotecnologia Vegetal, Universidade de Ribeirao Preto
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PESSOA Claudia
Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza
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MORAES Manoel
Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza
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COSTA-LOTUFO Leticia
Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza
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PEREIRA Marcio
Centra de Ciencias da Saude, Universidade de Fortaleza
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Franca Suzelei
Departamento De Biotecnologia Vegetal Universidade De Ribeirao Preto
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Bertoni Bianca
Departamento De Biotecnologia Vegetal Universidade De Ribeirao Preto
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Costa-lotufo Leticia
Department Of Physiology And Pharmacology School Of Medicine Federal University Of Ceara
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Pereira Ana
Departamento De Biotecnologia Vegetal Universidade De Ribeirao Preto
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