IDENTIFICATION OF NEW METABOLITES OF BUTYLATED HYDROXYTOLUENE (BHT) IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The urinary and fecal excretion of three new metabolites of butylated hydroxytoluene (BHT) were revealed by gas chromatography after intraperitoneal administration of this compound to male Wistar rats. The structures of these metabolites, 2,6-di-tert-butyl-p-benzoquinone (M-I), 2,6-di-tert-butylhydroquinone (M-II), and 2,6-di-tert-butyl-4-[(methylthio) methyl] phenol (M-III), were identified by comparison of gas chromatographic and mass spectral data with those of authentic samples. The possible formation of 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadien-1-one (1) as an intermediary metabolite to account for the occurrence of M-I was also discussed.
- 公益社団法人日本薬学会の論文
著者
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TAJIMA Kazuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
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Tajima K
Kanagawa Univ. Yokohama Jpn
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Tajima Kazuo
中華人民共和国
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Tajima K
Department Of Chemistry Hokuriku University
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Tajima K
High-tech Research Center Project Kanagawa University
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Tajima Kazuo
Department Of Materials Science Tokai University
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Tajima Kazuo
Department Of Chemistry Kanagawa University
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TAJIMA KAZUO
School of Pharmacy Hokuriku University
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YAMAMOTO KENJI
School of Pharmacy Hokuriku University
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MIZUTANI TAMIO
Faculty of Living Science, Kyoto Prefectural University
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Yamamoto K
Kaneka Corporation
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Mizutani T
Department Of Food Sciences And Nutritional Health Kyoto Prefectural University
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Mizutani Tamio
Department Of Food Science And Nutrition Kyoto Prefectural University
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Tajima K
Project Of Three-phase Emulsion Technol. Kanagawa Univ.
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Yamamoto Kenji
Department Of Chemistry Hokuriku University
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Yamamoto K
Kyushu Univ.
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