Design, Synthesis and Biological Activity of 7-O-(4-O-Acetyl-3-iodo-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)daunomycinone and 7-O-(3-Chloro-2,3,6-trideoxy-4-O-propanoyl-α-L-lyxo-hexopyranosyl)daunomycinone

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概要

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• The synthesis and pharmacological evaluation of 7-O-(4-O-acetyl-3-iodo-2,3,6-trideoxy-α-L-arabino-hexopy-ranosyl)daunomycinone and 7-O-(3-chloro-2,3,6-trideoxy-4-O-propanoyl-α-L-lyxo-hexopyranosyl)daunomycinone are described. Their cytotoxic activity was evaluated against normal and resistant cell lines. Both compounds exhibited activity against the adriamycin resistant cell line KB-A1. These results support the hypothesis that the increased lipophilicity of the sugar part of anthracyclines is associated with their ability to overcome multidrug resistance (MDR).

• 公益社団法人日本薬学会の論文
• 2000-01-01

著者

• Michel Sylvie

  Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De

• Leonce S

  Inst. Recherches Servier Croissy Sur Seine Fra

• Le´once S

  Institut De Recherches Servier Division Recherche Cancerologie

• LEONCE Stephane

  Institut de Recherches Servier, Division Recherche Cancerologie

• PIERRE Alain

  Institut de Recherches Servier, Division Recherche Cancerologie

• ALIGIANNIS Nectarios

  University of Athens, Department of Pharmacy, Division of Pharmacognosy

• POULI Nicole

  Division of Pharmaceutical Chemistry

• MARAKOS Panagiotis

  Division of Pharmaceutical Chemistry

• MITAKU Sofia

  University of Athens, Department of Pharmacy, Division of Pharmacognosy

• SKALTSOUNIS Alexios-Leandros

  University of Athens, Department of Pharmacy, Division of Pharmacognosy

• ATASSI Ghanem

  Institut de Recherches "SERVIER"

• Leonce Stephane

  Institut De Recherches Servier Division De Cancerologie Experimentale

• Pierre Alain

  Institut De Recherches Servier Division Recherche Cancerologie

• Mitaku S

  Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens

• Atassi G

  Inst. Res. Servier Suresnes Fra

• Pouli N

  Department Of Pharmacy. Division Of Pharmaceutical Chemistry University Of Athens

• Mitaku Sofia

  Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens

• Aligiannis Nektarios

  University Of Athens Department Of Pharmacy Division Of Pharmacognosy

• Skaltsounis A‐l

  University Of Athens Department Of Pharmacy Division Of Pharmacognosy

関連論文

• Synthesis and Cytotoxic Activity of Dimeric Analogs of Acronycine in the Benzo[b]pyrano[3,2-h]acridin-7-one Series
• Design, Synthesis, and Cytotoxic Activity of Michael Acceptors and Enol Esters in the Benzo[b]acronycine Series
• Synthesis and Cytotoxic and Antitumor Activity of 1,2-Dihydroxy-1,2-dihydrobenzo[b]acronycine Diacid Hemiesters and Carbamates
• Design, Synthesis and Biological Activity of 7-O-(4-O-Acetyl-3-iodo-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)daunomycinone and 7-O-(3-Chloro-2,3,6-trideoxy-4-O-propanoyl-α-L-lyxo-hexopyranosyl)daunomycinone
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