Synthesis and Cytotoxic Activity of Benzopyranoxanthone Analogues of Benzo[b]acronycine and Psorospermine
スポンサーリンク
概要
- 論文の詳細を見る
Condensation of 3-hydroxy-2-naphthalenecarboxylic acid with phloroglucinol afforded 1, 3-dihydroxy-12H-benzo[b]xanthen-12-one. Construction of an additional dimethylpyran ring onto this skeleton, by alkylation with 3-chloro-3-methyl-1-butyne followed by Claisen rearrangement, gave access to a series of benzo[b]pyrano[2, 3-i]xanthen-6-ones and benzo[b]pyranol[3, 2-h]xanthen-7-ones related to psorospermine and benzo[b]acronycine. In contrast with what is observed in the pyridoacridone and benzopyridoacridone series, the linear benzo[b]pyrano[2, 3-i]xanthen-6-one derivatives were more potent than their angular benzo[b]pyrano[3, 2-h]xanthen-7-one isomers. cis-3, 4-Diacetoxy-5-methoxy-2, 2-dimethyl-3, 4-dihydro-2H, 6H-benzo[b]pyrano[2, 3-i]xanthen-6-one, the most active among the new compounds, was more potent than acronycine in inhibiting the proliferation of L1210 murine leukemia cells.
- 公益社団法人日本薬学会の論文
- 2001-06-01
著者
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Koch Michel
Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De
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Michel Sylvie
Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De
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Koch M
Univ. Rene Descartes Paris Fra
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Pfeiffer Bruno
Institut De Recherches Servier Division Recherche Cancerologie
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TILLEQUIN Francois
Laboratoire de Pharmacognosie de l'Universite Paris Descartes
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PIERRE Alain
Institut de Recherches Servier, Division Recherche Cancerologie
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KOCH Michel
C.N.R.S. n°8638, Faculte des Sciences Pharmaceutiques et Biologiques
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PFEIFFER Bruno
C.N.R.S. n°8638, Faculte des Sciences Pharmaceutiques et Biologiques
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PIERRE Alain
C.N.R.S. n°8638, Faculte des Sciences Pharmaceutiques et Biologiques
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RENARD Pierre
Laboratoire de Pharmacognosie de l'Universite Rene Descartes, U.M.R.
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SITTISOMBUT Chavalit
Laboratoire de Pharmacognosie de l'Universite Rene Descartes, U.M.R.-C.N.R.S. n°8638, Faculte des Sc
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COSTES Nadine
C.N.R.S.n°8638, Faculte des Sciences Pharmaceutiques et Biologiques
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ATASSI Ghanem
Laboratoire de Pharmacognosie de l'Universite Rene Descartes, U.M.R.
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Pierre Alain
Institut De Recherches Servier Division Recherche Cancerologie
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Renard P
Laboratoire De Pharmacognosie De L'universite Rene Descartes U.m.r.
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Mitaku S
Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens
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Costes Nadine
C.n.r.s.n°8638 Faculte Des Sciences Pharmaceutiques Et Biologiques
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Atassi G
Inst. Res. Servier Suresnes Fra
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Tillequin Francois
Laboratoire De Pharmacognosie De L'universite Paris Descartes
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Tillequin F
Laboratoire De Pharmacognoise De 1'universite Rene Descartes Umr/cnrsn ^○8638 Faculte Des Scien
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Mitaku Sofia
Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens
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Sittisombut Chavalit
Laboratoire De Pharmacognosie De L'universite Rene Descartes U.m.r.-c.n.r.s. N°8638 Faculte Des
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Renard Pierre
Laboratoire De Pharmacognosie De L'universite Rene Descartes U.m.r.
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ATASSI Ghanem
Laboratoire de Pharmacognosie de l'Universite Rene Descartes, U.M.R.
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