Synthesis and Cytotoxic Activity of 11-Nitro and 11-Amino Derivatives of Acronycine and 6-Demethoxyacronycine

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概要

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• Condensation of 2-chloro-3-nitrobenzoic acid with either 5-amino-7-methoxy-2,2-dimethyl-2H-chromene or 5-amino-2,2-dimethyl-2H-chromene afforded diphenylamines 14 and 15. Trifluoroacetic anhydride mediated cyclization gave the corresponding acridones 16 and 17,which were subsequently N-methylated and reduced to 11-aminoacronycine and 11-amino-6-demethoxyacronycine.These two amino compounds, which gave stable water soluble salts, were 2- to 3-fold more potent than acronycine or 6-demethoxyacronycine in inhibiting L1210 cell proliferation.

• 公益社団法人日本薬学会の論文
• 1999-11-15

著者

• Koch Michel

  Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De

• Michel Sylvie

  Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De

• Koch M

  Univ. Rene Descartes Paris Fra

• SEGUIN Elisabeth

  Laboratoire de Pharmacognosie, UFR de Medecine Pharmacie Rouen

• TILLEQUIN Francois

  Laboratoire de Pharmacognosie de l'Universite Paris Descartes

• PIERRE Alain

  Institut de Recherches Servier, Division Recherche Cancerologie

• PIERRE Alain

  France and Institut de Recherche Servier

• ATASSI Ghanem

  France and Institut de Recherche Servier

• ELOMRI Abdelhakim

  Laboratoire de Pharmacognosie de l'Universite de Rouen-Haute Normandie

• Pierre Alain

  Institut De Recherches Servier Division Recherche Cancerologie

• Mitaku S

  Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens

• Atassi G

  Inst. Res. Servier Suresnes Fra

• Elomri Abdelhakim

  Laboratoire De Pharmacognosie De L'universite De Rouen-haute Normandie Umr 6014 Cnrs Faculte De

• Seguin Elisabeth

  Lab. De Pharmacognosie Ufr De Medecine Pharmacie Rouen

• Seguin Elisabeth

  Laboratoire De Pharmacognosie Ufr De Medecine Pharmacie Rouen

• Tillequin Francois

  Laboratoire De Pharmacognosie De L'universite Paris Descartes

• Tillequin F

  Laboratoire De Pharmacognoise De 1'universite Rene Descartes Umr/cnrsn ^○8638 Faculte Des Scien

• Mitaku Sofia

  Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens

• Seguin Elisabeth

  Laboratoire de Pharmacognosie de l'Universite de Rouen-Haute Normandie, UMR 6014 CNRS, Faculte de Pharmacie

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