Synthesis and Biological Evaluation of 6-(9-Hydroxy-5-methyl (and 5,6-Dimethyl)-6H-pyrido[4,3-b]carbazol-1-yl)picolinic Amides as New Olivacine Derivatives
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概要
- 論文の詳細を見る
Starting from 2-(6-methoxy-1-methylcarbazol-2-yl)ethylamine and diethyl-2,6-pyridine dicarboxylate, the title compounds were obtained through five or six steps. The new compounds retained significant cytotoxicity towards various tumor cell lines, but in vivo studies on murine P388 leukemia, B16 melanoma and Lewis lung carcinoma showed a lowered antitumor activity with respect to that of the related ovivacine lead compound 1.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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Kraus-berthier Laurence
C.n.r.s. N 8638 Faculte Des Sciences Pharmaceutiques Et Biologiques
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Leonce S
Inst. Recherches Servier Croissy Sur Seine Fra
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Guilbaud Nicolas
Institut De Recherches Servier Division De Cancerologie Experimentale
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Le´once S
Institut De Recherches Servier Division Recherche Cancerologie
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LEONCE Stephane
Institut de Recherches Servier, Division Recherche Cancerologie
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PIERRE Alain
Institut de Recherches Servier, Division Recherche Cancerologie
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ATASSI Ghanem
Institut de Recherches "SERVIER"
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LANDRAS Corinne
UMR 176 CNRS, Synthese Organique, Institut Curie Recherche
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JASZTOLD-HOWORKO Richard
UMR 176 CNRS, Synthese Organique, Institut Curie Recherche
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KRAUS-BERTHIER Laurence
Institut de Recherches Servier, Division de Cancerologie Experimentale
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GUILLONNEAU Claude
Institut de Recherches Servier, Division de Cancerologie Experimentale
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ROLLAND Yves
Institut de Recherches Servier, Division de Cancerologie Experimentale
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BISAGNI Emile
UMR 176 CNRS, Synthese Organique, Institut Curie Recherche
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Leonce Stephane
Institut De Recherches Servier Division De Cancerologie Experimentale
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Pierre Alain
Institut De Recherches Servier Division Recherche Cancerologie
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Rolland Yves
Institut De Recherche Servier
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Atassi G
Inst. Res. Servier Suresnes Fra
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Bisagni Emile
Umr 176 Cnrs Synthese Organique Institut Curie Recherche
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Landras Corinne
Umr 176 Cnrs Synthese Organique Institut Curie Recherche
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Jasztold-howorko Richard
Umr 176 Cnrs Synthese Organique Institut Curie Recherche:(present Address)zaklad Chemi Organicznej A
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Guillonneau Claude
Institut De Recherches Servier Division De Cancerologie Experimentale
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