Synthesis and Cytotoxic Activity of Pyranocarbazole Analogues of Ellipticine and Acronycine

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概要

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• Various 2, 2, 5, 11-tetramethyl- and 2, 2, 5, 6, 11-pentamethyl-2, 6-dihydropyrano [3, 2-b] carbazole derivatives were synthesized by condensation of 3-methylbut-2-enal or 3-chloro-3-methylbut-1-yne with an appropriate hydroxycarbazole. These compounds associate the tricyclic system responsible for the intercalating properties of ellipticine related drugs, with the dimethylpyran pharmacophore of acronycine derivatives. The study of the biological properties of the new pyrano [3, 2-b] carbazole derivatives was carried out in vitro on L1210 murine leukaemia cell line. The three (±)-cis-diol diesters 15, 16, and 18 were the most active compounds.

• 公益社団法人日本薬学会の論文
• 2004-05-01

著者

• Koch Michel

  Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De

• Michel Sylvie

  Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De

• Koch M

  Univ. Rene Descartes Paris Fra

• Pfeiffer Bruno

  Institut De Recherches Servier Division Recherche Cancerologie

• Nguyen-thi Thuan

  Laboratoire De Pharmacognosie De L'universite Rene Descartes

• TILLEQUIN Francois

  Laboratoire de Pharmacognosie de l'Universite Paris Descartes

• PIERRE Alain

  Institut de Recherches Servier, Division Recherche Cancerologie

• TRAN-THI Hong

  Laboratoire de Pharmacognosie de l'Universite Rene Descartes

• PFEIFFER Bruno

  Les Laboratories Servier, and Institut de Recherches Internationales Servier

• PIERRE Alain

  Division Recherche Cancerologie

• TRINH-VAN-DUFAT Hanh

  Laboratoire de Pharmacognosie de l'Universite Rene Descartes

• Pierre Alain

  Institut De Recherches Servier Division Recherche Cancerologie

• Mitaku S

  Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens

• Tran-thi Hong

  Laboratoire De Pharmacognosie De L'universite Rene Descartes

• Tillequin Francois

  Laboratoire De Pharmacognosie De L'universite Paris Descartes

• Tillequin F

  Laboratoire De Pharmacognoise De 1'universite Rene Descartes Umr/cnrsn ^○8638 Faculte Des Scien

• Mitaku Sofia

  Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens

• Trinh-Van-Dufat Hanh

  Laboratoire de Pharmacognosie de l'Université Paris Descartes, UMR/CNRS N° 8638, Faculté des Sciences Biologiques et Pharmaceutiques

• TRINH-VAN-DUFAT Hanh

  Laboratoire de Pharmacognosie de l'Universite Rene Descartes

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