A New Sphingolipid and Furanocoumarins with Antimicrobial Activity from Ficus exasperata
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概要
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From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2′,3′-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(－) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1–3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 µg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 µg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii.
著者
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Michel Sylvie
Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De
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WANSI Jean-Duplex
Department of Chemistry, Faculty of Science, University of Douala
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TRINH-VAN-DUFAT Hanh
Laboratoire de Pharmacognosie de l'Universite Rene Descartes
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Lallemand Marie-christine
Laboratoire De Pharmacognosie De L'universite Paris Descartes
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Dongfack Marlise
Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l’Université de Yaoundé-1, Faculté des Sciences
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Kuete Victor
Laboratory of Biochemistry, Department of Biochemistry, University of Dschang, Faculty of Science
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Mbazoa Céline
Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l’Université de Yaoundé-1, Faculté des Sciences
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Wandji Jean
Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l’Université de Yaoundé-1, Faculté des Sciences
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Wansi Jean-Duplex
Department of Chemistry, University of Douala, Faculty of Science
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Mbazoa Céline
Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l'Université de Yaoundé-1, Faculté des Sciences
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Trinh-Van-Dufat Hanh
Laboratoire de Pharmacognosie de l'Université Paris Descartes, UMR/CNRS N° 8638, Faculté des Sciences Biologiques et Pharmaceutiques
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Wandji Jean
Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l'Université de Yaoundé-1, Faculté des Sciences
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Dongfack Marlise
Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l'Université de Yaoundé-1, Faculté des Sciences
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Lallemand Marie-Christine
Laboratoire de Pharmacognosie de l'Université Paris Descartes, UMR/CNRS N° 8638, Faculté des Sciences Biologiques et Pharmaceutiques
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Michel Sylvie
Laboratoire de Pharmacognosie de l'Université Paris Descartes, UMR/CNRS N° 8638, Faculté des Sciences Biologiques et Pharmaceutiques
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Mbazoa Céline
Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l'Université de Yaoundé-1, Faculté des Sciences
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