Synthesis and Cytotoxic and Antitumor Activity of 1,2-Dihydroxy-1,2-dihydrobenzo[b]acronycine Diacid Hemiesters and Carbamates
スポンサーリンク
概要
- 論文の詳細を見る
A series of cis-1,2-dihydroxy-l,2-dihydrobenzo[b]acronycine diacid hemiesters and dicarbamates were prepared by acylation of cis-1,2-dihydroxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7H-benzo[b]pyrano[3,2-h]acridin-7-one. The cytotoxicity of the dicarbamates depended on the steric hindrance of the esterifying groups at positions 1 and 2. Diacid hemiesters displayed significant in vitro cytotoxic activities and induced cell cycle perturbations similar to those obtained with cis-1,2-diacetoxy-1,2-dihydrobenzo[b]acronycine (S23906-1) currently under preclinical development. cis-1-Acetoxy-2-hemiglutaryloxy-1,2-dihydrobenzo[b]acronycine was the most promizing compound of the series, inducing complete inhibition of tumor growth when tested against C38 colon adenocarcinoma implanted in mice.
- 公益社団法人日本薬学会の論文
- 2004-03-01
著者
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Kraus-berthier Laurence
C.n.r.s. N 8638 Faculte Des Sciences Pharmaceutiques Et Biologiques
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Koch Michel
Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De
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Michel Sylvie
Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De
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Leonce S
Inst. Recherches Servier Croissy Sur Seine Fra
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Doan Thi
Laboratoire De Pharmacognosie De L'universite Rene Descartes U. M. R. /c. N. R. S. N°8638 Facul
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Koch M
Univ. Rene Descartes Paris Fra
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Thi Mai
Laboratoire De Pharmacognosie De L'universite Rene Descartes U.m.r.
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Pfeiffer Bruno
Institut De Recherches Servier Division Recherche Cancerologie
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TILLEQUIN Francois
Laboratoire de Pharmacognosie de l'Universite Paris Descartes
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Le´once S
Institut De Recherches Servier Division Recherche Cancerologie
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PIERRE Alain
Institut de Recherches Servier, Division Recherche Cancerologie
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GASLONDE Thomas
C.N.R.S. n°8638, Faculte des Sciences Pharmaceutiques et Biologiques
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KOCH Michel
C.N.R.S. n°8638, Faculte des Sciences Pharmaceutiques et Biologiques
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PFEIFFER Bruno
C.N.R.S. n°8638, Faculte des Sciences Pharmaceutiques et Biologiques
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LEONCE Stephane
Laboratoire de Pharmacognosie de l'Universite Rene Descartes, U.M.R.
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PIERRE Alain
C.N.R.S. n°8638, Faculte des Sciences Pharmaceutiques et Biologiques
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RENARD Pierre
Laboratoire de Pharmacognosie de l'Universite Rene Descartes, U.M.R.
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Gaslonde Thomas
Laboratoire De Pharmacognosie De I'universite Rene Descartes U.m.r. C.n.r.s. N° 8638 Faculte De
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Pierre Alain
Institut De Recherches Servier Division Recherche Cancerologie
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Renard P
Laboratoire De Pharmacognosie De L'universite Rene Descartes U.m.r.
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Mitaku S
Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens
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Tillequin Francois
Laboratoire De Pharmacognosie De L'universite Paris Descartes
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Tillequin F
Laboratoire De Pharmacognoise De 1'universite Rene Descartes Umr/cnrsn ^○8638 Faculte Des Scien
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Mitaku Sofia
Laboratory Of Pharmacognosy Department Of Pharmacy University Of Athens
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Renard Pierre
Laboratoire De Pharmacognosie De L'universite Rene Descartes U.m.r.
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