Mass Spectrometry of Oxidation Products of Δ^1-and Δ^6-Tetrahydrocannabinols

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概要

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• The mass spectra of Δ^1-(Ia), Δ^6-tetrahydrocannabinol (Δ^6-THC) (IIa), 6α-(IIIa), 6β-hydroxy-(IVa), 7-hydroxy-Δ^1-THC (Va), 7-hydroxy-(VIa), 7-oxo-Δ^5-THC (VIIa), cannabinol (CBN, VIIIa), 6-hydroxy-(IXa), 7-hydroxy-(Xa), 7-oxo-CBN (XIa) and their acetyl derivatives were determined. Structure correlations and principal fragmentation pathways for these compounds were studied with the aid of the high resolution mass spectrometry and of d_3-acetyl derivatives. A typical fragmentation pattern was observed in both spectra of Δ^1-and Δ^6-THC series. The structure of the essential fragment ion for the compound mentioned above was well characterized by reasonable interpretation.

• 公益社団法人日本薬学会の論文
• 1976-09-25

著者

• 細谷 英吉

  Research Institute For Pharmacology:tsumura & Co.

• 稲山 誠一

  Pharmaceutical Institute, School of Medicine, Keio University

• 沢 愛子

  School of Medicine, Keio University

• 細谷 英吉

  Department of Pharmacology

• 細谷 栄吉

  Department Of Pharmacology:(present Address)kanebo Company

• 沢 愛子

  School Of Medicine Keio University

• 稲山 誠一

  Pharmaceutical Institute School Of Medicine Keio University

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