Distribution of Butylated Hydroxyanisole and Its Conjugates in the Tissues of Rats

概要

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The distribution of butylated hydroxyanisole (BHA) and its conjugates was investigated in the liver, kidney, pancreas, plasma and urine 1 and 3 hr after oral administration of ^3H-labeled BHA to rats. The total radioactivities in the tissues were in the order kidney>liver>plasma>pancreas. BHA-S (sulfate-conjugate) and BHA-G (glucuronideconjugate) could be separated clearly by paper electrophoresis. The radioactivities of BHA and its conjugates separated by electrophoresis were determined and the proportions of BHA, BHA-G and BHA-S were calculated. Unchanged BHA was mainly found in the liver and pancreas. The proportion of BHA-G increased in the order urine>kidney>plasma>pancreas>liver. On the other hand, that of BHA-S increased in the order plasma>kidney>pancreas>liver>urine. BHA-G was the major metabolite in urine and BHA-S was only a minor metabolite, but a considerable amount of BHA-S was found in plasma. Therefor, we investigated whether BHA-S administered intraperitoneally or intravenously is converted into the corresponding glucuronide to be excreted in urine. The results, however, showed that no significant amount of BHA-S was converted into BHA-G under the conditions used.
社団法人日本薬学会の論文
1981-05-23