Percutaneous Absorption of α-Olefin Sulfonate (AOS) in Rats

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Percutaneous absorption of α-olefin sulfonate (AOS) was investigated in rats by using ^<14>C-labeled compound. The solution of ^<14>C-AOS was applied to the dorsal skin under various conditions : (a) the intact skin dried naturally after application, (b) the intact skin wiped off 0.5 hr after application, (c) the intact skin wiped off 1.5 hr after application, (d) the intact skin with a plastic cup containing ^<14>C-AOS solution and (e) the damaged skin without the stratum corneum dried naturally after application. When rats were applied with 0.5 ml of a 0.2% solution of ^<14>C-AOS under the condition of (a), the recoveries of radioactivity were 0.33% in the urine, 0.08% in the bile and 0.21% in the main organs at 24 hr after application. It was thus estimated that the total amount absorbed through the skin was about 0.6% of the applied dose. Comparing the results obtained under the conditions of (a), (b) and (c), the percutaneous absorption of ^<14>C-AOS applied on the skin was almost finished by 1.5 hr after application. The excretion of radioactivity into the urine and bile was approached to the highest rate around 3-6 hr, then gradually decreased, and continued even 70-90 hr after application. When a 0.02% solution of ^<14>C-AOS was always in contact with the skin under the condition of (d), a small amount of the surfactant was continuously absorbed from the skin. On the other hand, when the skin was damaged and ^<14>C-AOS was applied on it under the condition of (e), a greater amount of radioactivity was excreted into the urine and bile, and the recoveries were 36.26% in the urine, 1.83% in the bile and 12.28% in the main organs 30 hr after application, being about 50% in total.
社団法人日本薬学会の論文
1977-04-25

Percutaneous Absorption of α-Olefin Sulfonate (AOS) in Rats

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