1,1'-Ethylene-bis(1-nitrosourea)(EBNU)の生化学的研究(第8報)EBNUおよび関連化合物によるラット肝臓クロマチンのカルバモイル化とその影響
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The binding of 1,1'-ethylene-bis (1-nitrosourea) (EBNU) [carbonyl-^<14>C], 1-ethyl-1-nitrosourea (ENU) [carbonyl-^<14>C], ^<14>C-potassium cyanate (KCNO), and acetic anhydride [1-^<14>C], to rat liver chromatin was compared in vitro. The order of binding was acetic anhydride&GiEBNU>ENU>KCNO. The effects of various kinds of acylating agents (alkyl isocyanate, alkyl isothiocyanate, N-nitrosourea, KCNO, and acetic anhydride) on template activity of rat liver chromatin were compared by using exogenous bacterial DNA-dependent RNA polymerase system. The template activity was extremely increased by acetic anhydride, and slightly increased by KCNO and some alkyl isocyanates (methyl, ethyl, n-propyl, and n-butyl). The chromatin reacting with EBNU and KCNO was slightly more sensitive than the control chromatin to DNase I and Staphylococcal nuclease. We also compared the solubility of control chromatin and EBNU-and KCNO-reacted chromatin in various concentrations of magnesium chloride and calcium chloride. The solubility of carbamoylated chromatin by EBNU or KCNO was clearly higher than that of the control chromatin in the presence of magnesium or calcium ion.
- 社団法人日本薬学会の論文
- 1982-09-25
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