Metabolism, Distribution and Excretion of 2,2,3,3,3-Pentafluoropropanol in Rats

スポンサーリンク

概要

• 論文の詳細を見る

• The elimination and metabolism of 2,2,2,3,3-pentafluoropropanol (5-FP) were investigated in male and female rats for 7 d after a single oral administration at doses of 4,40,and 400 mg/kg. 5-FP glucuronide and 2,2,3,3,3-pentafluoropropionic acid (5-FPA) as major metabolites were determined by head-space analysis using GC-MS in the selected ion monitoring-mode. 5-FP glucuronide and 5-FPA were found in urine and feces of both male and female rats. The cumulative excretion of 5-FP in the urine was 28.6-59.3% of the dose and only 0.46-1.28% in the feces in both sexes. A sex-related difference in urinary excretion of 5-FPA was observed in the two dose levels (4 and 40 mg/kg). The recoveries of 5-FPA in the urine of rats administered 5-FP were 10.7-11.9% in male and 33.0-38.2% in female by 7 d post treatment. The sex-related difference of biological half-lives (t_<1/2>) were also observed in some tissues such as liver, kidney and blood.

• 1996-02-29

著者

• 高橋 惇

  Division Of Xenobiotic Metabolism And Disposition National Institute Of Health Sciences

• 嶺岸 謙一郎

  Division of Xenobiotic Metabolism and Disposition National Institute of Health Sciences

• 高橋 惇

  Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences

関連論文

• Distribution, Accumulation and Excretion of N, N'-Dimonomethylphenyl-p-phenylenediamine in the 2 Year Feeding Test in Rats
• 生薬エキスの生体影響に関する毒性学的研究 : 芍薬, 桃仁, 当帰および川〓
• G-CSFによるHL-60細胞の活性酸素生成酵素の機能的成熟とそれに関わる因子の解析-II
• Distribution of Butylated Hydroxyanisole and Its Conjugates in the Tissues of Rats
• G-CSFによるHL-60細胞の活性酸素生成能の促進とセラミドの関与について
• 白血球の活性化とコフィリンの動態
• ラット肝細胞でのapoB48含有VLDL粒子の形成機構
• Metabolism, Distribution and Excretion of 2,2,3,3,3-Pentafluoropropanol in Rats

スポンサーリンク