A Practical Synthetic Method for 3-(N, N-Disubstituted Carbamoyloxy)-methyl Cephems without Generating the Δ^2-Isomers
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概要
- 論文の詳細を見る
E1101,a new oral caphalosporin, has a (N, N-dimethylcarbamoyloxy)methyl group at the C-3 position of the cephem nucleus. The previous methods for manufacturing 3-(N, N-disubstituted carbamoyloxy)methyl cephems generate various amounts of intractable Δ^2 isomers as by-products. In this report, we describe a new, practical synthetic method for cephems of this type without generating Δ^2 isomers, via 7-acylamino-3-(4-nitrophenoxy-carbonyloxy)methyl-Δ^3-cephem-4-carboxylic acid (5) as a key intermediate.
- 公益社団法人日本薬学会の論文
- 1995-06-15
著者
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鎌田 厚
Eisai Co. Ltd. Tsukuba Research Laboratories
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Kamada Atsushi
Eisai Co. Ltd. Tsukuba Research Laboratories
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Negi S
Eisai Co. Ltd. Kashima Plant Process Chemistry Research Laboratories
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山中 基資
Eisai Tsukuba Research Laboratories
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Komatsu Y
National Institute Of Advanced Industrial Science And Technology
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小松 雄毅
Eisai Tsukuba Research Laboratories
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Tsukada Itaru
Tsukuba Research Laboratories Eisai Co. Ltd.
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塚田 格
Eisai Co. Ltd. Tsukuba Research Laboratories
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根木 茂人
Eisai Co., Ltd., Tsukuba Research Laboratories
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鶴岡 明彦
Eisai Co., Ltd., Tsukuba Research Laboratories
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町田 善正
Eisai Co., Ltd., Tsukuba Research Laboratories
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根木 茂人
Eisai Co. Ltd. Kashima Plant Process Chemistry Research Laboratories
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山中 基資
Eisai Co. Ltd. Tsukuba Research Laboratories
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鶴岡 明彦
Tsukuba Research Laboratories Eisai Co. Ltd.
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町田 善正
Eisai Co. Ltd. Tsukuba Research Laboratories
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Machida Yoshimasa
Eisai Co. Ltd. Tsukuba Research Laboratories
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根木 茂人
Eisai Co. Ltd. Tsukuba Research Laboratories
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