Regulation of Ribozyme Activity with Short Oligonucleotides (Biological and Pharmaceutical Aspects of Nucleic Acids Chemistry)
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概要
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Both hammerhead and hairpin ribozymes, which are well known as small catalytic RNAs, can catalyze either cleavage or ligation of RNA with sequence specificity. Although they have been applied to gene therapy and gene discovery, by cutting the mRNAs of target genes, these ribozymes normally do not have the ability to regulate their catalytic activities. Therefore, allosteric control has been applied to the ribozymes. Watson-Crick base pairing has superior ability in molecular recognition, and the sequence of nucleic acids makes diversity of molecules possible. Therefore, we have tried to construct a new ribozyme of which activity is regulated by a specific oligonucleotide. The allosteric ribozyme has potentials of not only regulation of activity but also a sensor for gene expression.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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Komatsu Yasuo
National Institute of Advanced Industrial Science and Technology (AIST)
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Komatsu Y
National Institute Of Advanced Industrial Science And Technology
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