Synthesis and Antifungal Activity of Novel Thiazole-Containing Triazole Antifungals. II. Optically Active ER-30346 and Its Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A series of novel thiazole-containing triazole antifungals was synthesized and evaluated for antifungal activity against a variety of clinically isolated pathogenic fungi in vitro and against systemic candidosis in vivo. These compounds showed potent antifungal activities in vitro and in vivo. In particular, (2R, 3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (12g; ER-30346) showed potent and well-balanced in vitro activities and potent in vivo efficacy, and had a good safety profile.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
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NAITO Takeaki
Kobe Pharmaceutical University
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NARA Kazumasa
Tsukuba Research Laboratories, Eisai Co., Ltd.
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Yanagisawa Manabu
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Naito T
Kobe Pharmaceutical University
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Nara K
Eisai Co. Ltd. Ibaraki Jpn
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KAKU Yumiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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TSURUOKA Akihiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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KAKINUMA Hiroyuki
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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TSUKADA Itaru
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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YANAGISAWA Manabu
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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NAITO Toshihiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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Yanagisawa M
Institute Of Materials Science University Of Tsukuba
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Kaku Yumiko
Tsukuba Research Laboratories Eisai Co. Ltd.
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Tsukada Itaru
Tsukuba Research Laboratories Eisai Co. Ltd.
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塚田 格
Eisai Co. Ltd. Tsukuba Research Laboratories
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鶴岡 明彦
Tsukuba Research Laboratories Eisai Co. Ltd.
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Nara Kazumasa
Tsukuba Research Laboratories Eisai Co. Ltd.
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Kakinuma Hiroyuki
Tsukuba Research Laboratories Eisai Co. Ltd.
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