Stereoselective Synthesis of β-Hydroxyphenylalanines Using Imino 1, 2-Wittig Rearrangement of Hydroximates
スポンサーリンク
概要
- 論文の詳細を見る
The imino 1, 2-Wittig rearrangement of hydroximates containing a furan ring provides a novel method for the synthesis of β-hydroxy-α-amino acids. Upon treatment with LDA, hydroximates smoothly underwent the rearrangement to give Z-2-hydroxyoxime ethers in good yield, which were converted into both cis- and trans-oxazolidinones with high stereoselectivity. The cis- and trans-oxazolidinones were stereoselectively converted into erythro- and threo-β-hydroxyphenylalanines, respectively, via the oxidative cleavage of a furan ring, ring-opening of oxazolidinone, and deprotection.
- 公益社団法人日本薬学会の論文
- 2005-04-01
著者
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NAITO Takeaki
Kobe Pharmaceutical University
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Naito Takeaki
Kobe Pharmaceutical Univ.
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MIYATA Okiko
Kobe Pharmaceutical University
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ASAI Hiroshi
Kobe Pharmaceutical University
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Miyata Okiko
Kobe Pharmaceutical Univ.
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