A Novel Route for Chiral Synthesis of the Triazole Antifungal ER-30346
スポンサーリンク
概要
- 論文の詳細を見る
A novel synthetic route to (2S, 3S)-2-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1-(1,2,4-triazolyl))butyronitrile (2), an intermediate for the orally active triazole antifungal agent ER-30346,was developed from methyl S-(+)-3-hydroxy-2-methylpropionate, a commercially available chiral compound. The second chiral center was constructed with 6.4 : 1 diastereoselectivity via osmium tetroxide catalyzed dihydroxylation.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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NAITO Takeaki
Kobe Pharmaceutical University
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Yanagisawa Manabu
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Naito T
Kobe Pharmaceutical University
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KAKU Yumiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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TSURUOKA Akihiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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KAKINUMA Hiroyuki
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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TSUKADA Itaru
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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YANAGISAWA Manabu
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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NAITO Toshihiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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Yanagisawa M
Institute Of Materials Science University Of Tsukuba
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Kaku Yumiko
Tsukuba Research Laboratories Eisai Co. Ltd.
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Tsukada Itaru
Tsukuba Research Laboratories Eisai Co. Ltd.
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塚田 格
Eisai Co. Ltd. Tsukuba Research Laboratories
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鶴岡 明彦
Tsukuba Research Laboratories Eisai Co. Ltd.
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Kakinuma Hiroyuki
Tsukuba Research Laboratories Eisai Co. Ltd.
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