Synthesis and Antifungal Activity of Novel Thiazole-Containing Triazole Antifungals
スポンサーリンク
概要
- 論文の詳細を見る
A new series of thiazole-containing triazole antifungals was synthesized and evaluated for antifungal activity against a variety of clinically isolated pathogenic fungi in vitro and against systemic candidosis in vivo. Among these compounds, (±)-1-(2,4-difluorophenyl)-1-[4-(2,4-difluorophenyl)thiazol-2-yl]-2-(1H-1,2,4-triazol-1-yl)ethanol (ER-24161) showed the most potent and well-balanced in vitro activities and excellent in vivo efficacy. We also achieved an enantioselective synthesis of the more potent enantiomer of ER-24161.
- 公益社団法人日本薬学会の論文
- 1997-07-15
著者
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NAITO Takeaki
Kobe Pharmaceutical University
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Yanagisawa Manabu
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Naito T
Kobe Pharmaceutical University
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KAKU Yumiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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TSURUOKA Akihiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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KAKINUMA Hiroyuki
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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TSUKADA Itaru
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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YANAGISAWA Manabu
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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NAITO Toshihiko
Tsukuba Research Laboratories, Eisai Co. Ltd.,
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Yanagisawa M
Institute Of Materials Science University Of Tsukuba
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Kaku Yumiko
Tsukuba Research Laboratories Eisai Co. Ltd.
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Tsukada Itaru
Tsukuba Research Laboratories Eisai Co. Ltd.
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塚田 格
Eisai Co. Ltd. Tsukuba Research Laboratories
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鶴岡 明彦
Tsukuba Research Laboratories Eisai Co. Ltd.
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Kakinuma Hiroyuki
Tsukuba Research Laboratories Eisai Co. Ltd.
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