Synthesis of a Novel Dual Inhibitor of Thromboxane A_2 Synthetase and 5-Lipoxygenase (E3040) via the Direct Coupling Reaction of Hydroquinone with 3-Pyridinecarboealdehyde
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概要
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Synthesis of a novel dual inhibitor of thromboxane A_2 synthetase and 5-lipoxygenase, 5,7-dimethyl-6-hydroxy-2-methylamino-4-(3-pyridylmethyl)benzothiazole (E3040), was accomplished via a new coupling reaction, in which a key intermediate, (3,6-dihydroxy-2,4-dimethylphenyl)-(3-pyridyl)methanol, was easily synthesized in a high yield from 2,6-dimethyl-1,4-benzohydroquinone and 3-pyridinecarboxaldehyde in 6N hydrochloric acid. The regio isomers of 3-pyridinecarboxaldehyde also gave the corresponding coupling products in high yields.
- 公益社団法人日本薬学会の論文
- 1995-10-15
著者
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南 法夫
Eisai Tsukuba Research Laboratories
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南 法夫
Research Laboratories Eisai Co. Ltd.
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小松 雄毅
Eisai Tsukuba Research Laboratories
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Komatsu Yuki
Eisai Tsukuba Research Laboratories
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- Synthesis of a Novel Dual Inhibitor of Thromboxane A_2 Synthetase and 5-Lipoxygenase (E3040) via the Direct Coupling Reaction of Hydroquinone with 3-Pyridinecarboealdehyde
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