Reduction of o-Acylphenols through Ethyl o-Acylphenylcarbonates to o-Alkylphenols with Sodium Borohydride

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概要

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• It was found that the ethoxycarbonyl derivatives of o-acylphenols were reduced to the corresponding o-alkylphenols by sodium borohydride under mild conditions ; the use of 3 molar equivalents of sodium borohydride was sufficient for this reduction. Various kinds of o-acylphenols (1,3,5,7,9,11,13,15,17,19,21,23,25 and 27) were reduced to the corresponding o-alkylphenols (2,4,6,8,10,12,14,16,18,20,24,26 and 28,respectively) in high yield by this method. o-acetylphenyl acetate (29) afforded o-ethylphenol (8) in better yield with sodium borohydride than ethyl o-acetylphenylcarbonate, but o-acetyl-phenyl p-toluenesulfonate (30) did not give 8.

• 公益社団法人日本薬学会の論文
• 1979-06-25

著者

• 南 法夫

  Eisai Tsukuba Research Laboratories

• 南 法夫

  Research Laboratories Eisai Co. Ltd.

• 貴島 静正

  Research Laboratories, Eisai Co., Ltd.

• 貴島 静正

  Research Laboratories Eisai Co. Ltd.

• 南 法夫

  Research Division, Teikoku Hormone Manufacturing Co., Ltd.,

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• Reduction of o-Acylphenols through Ethyl o-Acylphenylcarbonates to o-Alkylphenols with Sodium Borohydride
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