Synthesis and Cardiovascular Activity of Phenylalkylamine Derivatives. I. Potential Specific Bradycardic Agents
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概要
- 論文の詳細を見る
A series of acyclic amide derivatives of N-(ω-aminoalkyl)-N-methylhomoveratrylamine was synthesized and evaluated for their bradycardic activity in isolated guinea pig right atria. Among these compounds, (E)-N-[3-[N'-2-(3,4-dimethoxyphenyl)ethyl]-N'-methylamino]propyl]-4-[3,4-(methylenedioxy)phenyl]-3-butenamide (35) was the most potent in vitro and was also found to show dose-dependent bradycardia without remarkable reduction of left ventricular dp/dt_<max> or mean aortic pressure in anesthetized dogs.
- 公益社団法人日本薬学会の論文
- 1992-10-25
著者
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松倉 正幸
Eisai Tsukuba Research Laboratories
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南 法夫
Eisai Tsukuba Research Laboratories
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尾崎 文博
Eisai Tsukuba Research Laboratories
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南 法夫
Research Laboratories Eisai Co. Ltd.
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樺沢 靖弘
Eisai Tsukuba Research Laboratories
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石橋 恵治
Eisai Tsukuba Research Laboratories
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池森 恵
Eisai Tsukuba Research Laboratories
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浜野 祐之
Eisai Tsukuba Research Laboratories
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