Synthesis and Antiarrhythmic Activity of 2,2-Dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4,4'-imidazolidine]-2', 5'-diones
スポンサーリンク
概要
- 論文の詳細を見る
A novel series of 2,2-dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4,4'-imidazolidine]-2', 5'-diones was synthesized and evaluated for antiarrhythmic activity in chloroform- or/and aconitine-induced ventricular arrhythmia in mice. Among these compounds, (-)-6-chloro-2,2-dimethyl-1'-[3-(4-hydroxypiperidino)propyl]-spiro-[chroman-4,4'-imidazolidine]-2', 5'-dione was found to be more effective than reference agents and was selected for further development.
- 社団法人日本薬学会の論文
- 1992-07-25
著者
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田中 悟
Eisai Tsukuba Research Laboratories
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松倉 正幸
Eisai Tsukuba Research Laboratories
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大工 嘉治
Eisai Tsukuba Research Laboratories
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上田 耕一郎
Eisai Tsukuba Research Laboratories
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五十嵐 俊二
Eisai Tsukuba Research Laboratories
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南 法夫
Eisai Tsukuba Research Laboratories
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田中 悟
エーザイ株式会社 研究開発本部
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南 法夫
Research Laboratories Eisai Co. Ltd.
関連論文
- Synthesis and Antiarrhythmic Activity of 2,2-Dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4,4'-imidazolidine]-2', 5'-diones
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