Hydrophobicity Parameters Determined by Reversed-Phase Liquid Chromatography. II. Dependence of Retention Behavior of Pyrazines on Mobile Phase Composition
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概要
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The retention behavior of monosubstituted pyrazines was investigated by comparing the hydrophobic contribution of each substituent (κ) to the capacity factor obtaiend from reversed-phase high-performance liquid chromatography (HPLC), using a C_<18> capsule-type column and methanol-water eluents of various compositions. The mobile phase dependency of κ showed that the retention mechanism varied with the substituent, especially in mobile phases with very high water content, due to the intervention of the selective solute-solvent interactions. Under such circumstances, the capacity factor (log k') obtaiend from HPLC methods correlated very poorly with the octanol-water partition coefficient (log P). The log k' for pyrazines with only alkyl and/or alkoxy groups was measured and the correlation with log P was examined. An excellent linear correlation was obtained with the eluent containing about 30% methanol. However, at other methanol concentrations, the log k' values of the alkyl and alkoxy derivatives correlated with log P by two separated linear equations. The use of log k_W (log k' at 100% water), which has so far been considered to be the best index of hydrophobicity, failed to simulate log P.
- 公益社団法人日本薬学会の論文
- 1991-05-25
著者
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高尾 楢雄
Kobe Women's College of Pharmacy
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山上 知佐子
Kobe Women's College of Pharmacy
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山上 知佐子
神戸薬科大学
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高尾 楢雄
Kobe Women's College Of Pharmacy
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山上 知佐子
Kobe Pharmaceutical University
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