Comparative Studies of the Influence of Dietary Fat on Plasma Levels of Isosorbide Dinitrate from Two Sustained-Release Products

概要

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The influence of dietary fat intake on the plasma levels and bioavailability of isosorbide dinitrate (ISDN) from two sustained-release formulations was examined in ten healthy volunteers by mean of an open crossover trial. Each subject orally received one mixed granule type product(formulation A) and one diffused-sustained-release type product (formulation B). The plasma level of ISDN rapidly increased to the maximum level within 3-5h after administration of each product in subjects on a fatty diet. The mean enhancements were 84.5% for formulation A and 61.2% for formulation B compared with the levels in subjects on fat-free diet. The area under the curve(AUC_<0-10>) values of the former in subjects fed dietary fat were significantly greater than the preprandial figures, but no significant difference was observed with the latter product.
社団法人日本薬学会の論文
1986-07-25