結節性多発性動脈炎を疑われた症例におけるCyclosporin Aの臨床的効果と血中濃度モニタリング

概要

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Prednisolone (40 mg/day) and cyclosporin A (200 mg/day) were administrated in a patient suspected of suffering from Polyarteritis nodosa. To avoid steroidal side effects, the prednisolone dose decreased to 20-40 mg every other day. Since the cyclosporin A trough concentration was high ( 310 ng/ml) for a dose of 200 mg/day, the dose was decreased to 100 mg/day. The patient complained of severe numbness in her left leg and hands and a decreased grasping power while talking the reduced doses, and her trough levels of cyclosporin A was 30.0-46.8 ng/ml. When the cyclosporin A dose was increased to 150 mg/day, the patient's numbness in her left leg and her grasping power improved. and her cyclosporin A trough level was 71-86.3 ng/ml. The prednisolone dose was not changed while the dose of cyclosporin A was increased. There were no serious side effects while administration of cyclosporin A. These findings suggested that co-administered cyclosporin helps to decrease the occurrence of numbness and while also improving the grasping power in patients suspected of suffering from Polyarteritis nodosa who receiving steroid therapy.
日本医療薬学会の論文
1999-12-10