5-フルオロウラシルドライシロップエマルジョンの製法と組織内分布

概要

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In order to obtain stable oral emulsion of 5-fluorouracil (5-FU) dry syrup, kind of surfactants and the ratio of their combination, as well as the method of preparation of the emulsion and its physical stability were studied. In the study, a method of preparation was established : Sesame oil and surfactants (HCO-60, MGS-B : HLB=10.4) were dissolved in oil phase, and 5-FU dry syrup in water phase. Then, 2 phases were heated to 70°and the emulsion (o/w type) was obtained by ultrasonic vibrations. Anti bacterial effect of the 5-FU emulsion was studied. The potency was not reduced even after storage for 30 days. The emulsion was comparatively stable when stored at room temperature. In the study of tissue distribut1on, the AUC level of 5-FU in the lymph node of mice after oral administration of the emulsion was higher than the concentration after administration of 5-FU dry syrup solution. The 5-FU emulsion showed excellent lymphotrophic effect, thus proving that it is clinically very useful.
日本医療薬学会の論文
1980-05-20