Effect of Parotid Gland Hypocalcemic Factor on Increasing Antibody-producing Cells in Mice

概要

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The hypocalcemic substance isolated from bovine parotid gland and the fractions obtained in process of purification were examined for increasing antibody-producing cells (PFC activity) in the spleen of ICR mice by the method of Jerne and Nordin, and for lymphocyte-increasing action in mice. The intraperitoneal injection of the final purified sample in a dose of 10 μg/mouse produced 79.20±15.73 of PFC number per 10^6 cells in the spleen of neonatal mice. The difference between the mean of PFC number in the test group and that in the control group was significant at 5% level of significance. The final purified product was increased in PFC activity by 10 times that of the acetone-dried powder (starting material). A tendency to the increase in PFC activity and in lymphocytes increasing activity was found in proportion to the increase in hypocalcemic activity. Therefore, it was found that there was an action of promoting immune competence in the hypocalcemic substance. Further, the immunoactivities of parotid hypocalcemic substance were discussed in comparison with the thymic hypocalcemic substances.
公益社団法人日本薬学会の論文
1977-07-25