Antitumor Activity of P-MSY, a Protein from Bovine Parotid Glands, and Some Observations relating to the Activity

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概要

• 論文の詳細を見る

• When P-MSY, a component of bovine parotid glands, was injected at a dose of 1μg/head/d, daily for 10 d starting 24 h after the transplantation of ascites Ehrlich carcinoma cells, the solid tumor formed was rejected in 6 of 10 mice, and the tumor inhibition rate was 86.4%. Subcutaneous injection of 1μg/head/d, daily for 7 d before transplantation of sarcoma-180 cells resulted in prolongation of the life span of ascites tumor-bearing mice, the mean survival period being 19.4 d against 14.1 d in the control ; T/C was 138%. Such a life-prolonging effect was not observed when P-MSY was administered after the transplantation of the tumor. Electrophoresis of the serum from mice in which the tumor had been rejected after the administration of P-MSY revealed increased quantities of some protein components. By examinations of delayed-type skin reaction, P-MSY was found to hinder significantly the lowering of cellular immunity in tumor-bearing mice.

• 公益社団法人日本薬学会の論文
• 1982-06-25

著者

• 鈴木 郁功

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 山本 肇

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 水谷 彰

  Daiyukai Institute of Medical Sciences, The 2nd Division

• 水谷 彰

  Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address) The 2nd Division Daiyuka

• 鈴木 郁功

  Faculty Of Pharmaceutical Sciences Nagoya City University

関連論文

• Sequence Determination of Amino- and Carboxyl-Terminal Residues of Hypocalcemic Profein TP_1 extracted from Bovine Thymus Gland
• Some Properties of Bovine Thymic Hypocalcemic Factor TP1
• Effect of Bovine Thymic Hypocalcemic Factor on Increasing Antibody-producing Cells in Mice
• Purification and Characterization of Hypocalcemic Protein from Porcine Parotid Gland
• An Active Core in a Limited Chymotryptic Digest of Bovine Parotid Hypocalcemic Substance
• Effect of Hypocalcemic Protein P-MSY obtained from Bovine Parotid Gland on the Cyclic Adenosine-5'-monophosphate and Cyclic Guanosine-5'-monophosphate Contents of Murine Thymus and Spleen Cells
• Antitumor Activity of P-MSY, a Protein from Bovine Parotid Glands, and Some Observations relating to the Activity
• Effects on Antibody-Producing Cells and Peripheral Bloody Lymphocyte Subpopulations (T- and B-cells) of P-MSY, a Substance with Antitumor Activity from Bovine Parotid Gland
• Purification and Characterization of Bovine Parotid Hypocalcemic Factor obtained via Extraction with Glacial Acetic Acid
• Antitumor Activity of Bovine Parotid Hypocalcemic Substance Obtained by Glacial Acetic Acid Extraction
• Immune Competence-Promoting Action of Bovine Parotid Hypocalcemic Factor obtained via Extraction with Glacial Acetic Acid
• Evidence for Non-mediation of Calcitonin in the Action of Hypocalcemic Protein from Bovine Parotid Gland
• Chemical Modification of the Bovine Parotid Hypocalcemic Protein
• Circular Dichroism of a Hypocalcemic Protein in Bovine Parotid Gland
• Effect of Parotid Gland Hypocalcemic Factor on Increasing Antibody-producing Cells in Mice
• Amino- and Carboxyl-terminal Sequences of a Hypocalcemic Protein Isolated from Bovine Parotid Gland
• Molecular Weight Determination and the Secondary Structure of the Hypocalcemic Protein purified from Bovine Parotid Gland
• Isolation of a Hypocalcemic Substance in Bovine Parotid Gland, and Some Properties of this Substance
• Determination of the Amino- and Carboxyl-terminal Residues of an Immuno-competence Promoting Protein, P-MSY, from Bovine Parotid Glands
• The Influence of Bovine Thymus Hypocalcemic Protein, TP1,on the Levels of Cyclic Nucleotides in Murine Thymus Lymphocytes
• Isolation of a Deoxyribonuclease from Bovine Parotid Gland

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