Suppression of IgM-producing Cells by Administration of Anti-IgM Serum in Vivo before Sheep Red Blood Cells Injection
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概要
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The primary immune response in young adult mice to sheep red blood cells was studied by following the effects of anti-IgM or anti-Fc sera on the number of plaqueforming cells for IgM (dPFC) and IgG (iPFC) in the spleen. The number of dPFC in the case of administration of anti-IgM serum at 1 h before antigen injection was significantly decreased to 3.7±0.9/10^6 spleen cells in comparison with the value of control serum (69.0±15.7/10^6 spleen cells). However, the numbers of iPFC in the cases of both anti-IgM or control sera were similar. From these results, we suppose that progenitors of IgM-producing cells are different from progenitors of IgG-producing cells in adult mice.
- 公益社団法人日本薬学会の論文
- 1982-05-25
著者
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木村 仁美
Faculty Of Pharmaceutical Sciences Nagoya City University
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水谷 隆治
Faculty of Pharmaceutical Sciences, Nagoya City University
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和木 薫子
Faculty of Pharmaceutical Sciences, Nagoya City University
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岡山 球美
Faculty of Pharmaceutical Sciences, Nagoya City University
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水谷 隆治
Faculty Of Pharmaceutical Sciences Nagoya City University
-
岡山 球美
Faculty Of Pharmaceutical Sciences Nagoya City University
-
和木 薫子
Faculty Of Pharmaceutical Sciences Nagoya City University
-
水谷 隆治
Faculty of Pharmaceutical Sciences
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