Studies on Acetylenic Compounds. XXX. Absolute Configuration of 1,4-Diphenyl-2-butyn-1,4-diol.
スポンサーリンク
概要
- 論文の詳細を見る
1 (R), 4 (R)-(-)-1,4-Diphenyl-2-butyn-1,4-diol (IIIb) was obtained accompanying with the meso-diol (IIIa) by Grignard reaction of (R)-(-)-1-phenyl-2-propyn-1-ol and benzaldehyde. Each of diasteroisomers was oxidized with manganese dioxide to the same 1,4-diphenyl-2-butyn-1,4-dione. The levorotatory glycol (IIIb) was derived to the corresponding diacetate V, which was oxidized with aqueous potassium permanganate into O-acetyl-(S)-(+)-mandelic acid (VI) and the absolute configuration of IIIb was further confirmed as (R) -system. 1 (S), 4 (S)-(+)-1,4-Diphenyl-2-butyn-1,4-diol (IIIc) was similarly obtained from (S)-(+)-1-phenyl-2-propyn-1-ol and benzaldehyde. A stoichiometric mixture of the enantiomorphs (IIIb and IIIc) gave the racemic compound IV melted at 101〜102°.
- 公益社団法人日本薬学会の論文
- 1963-04-25
著者
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富田 和男
Agricultural Chemicals Research Laboratories Sankyo Co. Ltd.
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岩井 一成
Takamine Laboratory, Sankyo Co., Ltd.
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富田 和男
Takamine Laboratory, Sankyo Co., Ltd.
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岩井 一成
Central Research Laboratories Sankyo Co. Ltd.
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