A New Potent Non-narcotic Antitussive, 1-Methyl-3-di (2-thienyl) methylenepiperidine. Pharmacology and Clinical Efficacy.
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概要
- 論文の詳細を見る
1-Methyl-3-di (2-thienyl) methylenepiperidine citrate (AT-327) showed antitussive effect more potent than codeine in unanesthetized dogs and effect approximately equal to codeine in pentobarbitalized cats. The efficacy was also demonstrated in clinical trials with 45 patients. The antitussive activity seemed to be due to its direct action on the cough center per se. The drug did not show any analgesic activity, tendency of establishing tolerance, or indicate addiction liability, either in animal experiments or in clinical trials. The toxicity was found to be lower than that of codeine in the mouse. Other pharmacological properties of the drug were also discussed briefly.
- 公益社団法人日本薬学会の論文
- 1959-05-10
著者
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加瀬 佳年
熊本大学薬学部
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近藤 功
The Internal Clinic Of The Kumamoto Central Hospital
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加瀬 佳年
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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由井薗 倫一
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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山崎 徳二
the Internal Clinic of the Kumamoto Central Hospital
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山田 知章
the Internal Clinic of the Kumamoto Central Hospital
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井尾 重雄
the Internal Clinic of the Kumamoto Central Hospital
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田宮 又男
the Internal Clinic of the Kumamoto Central Hospital
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