d-3-Dimethylamino-1,1-diphenylbutyl Ethyl Sulfone as a Long-acting Antitussive.

概要

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I. Pharmacology 1) Antitussive effect : The comparison of antitussive effect of Win-1161-3 with other control drugs is shown in Table I. the 2nd Internal Clinic of this University. The classification of patients was pulmonary tuberculosis with cavity, bronchitis, and bronchial asthma. Average daily dose of the drug administered orally was 1〜2mg. for the children and 4〜6mg. for adults. The classification of the effect was as follows : For pulmonary tuberculosis (17 patients), remarkably effective (5/17), effective (12/17). ineffective (0/17) ; for bronchial asthma and bronchitis (20 patients), remarkably effective (16/20), effective (1/20), ineffective (3/20). It seemed that 6 mg. is sufficient to maintain the effect for a day for adults. The antitussive effect of the drug (3〜4mg.) was compared with those of Dextromethorphan (40 mg.) and codeine (60 mg.) in 17 tuberculosis patients. The effect was the most marked with Win-1161-3,followed by Dextromethorphan and codeine. No side-effect (especially tolerance and cumulation) was observed in 4 tuberculosis patients who were given 6 mg. daily dose of the drug for 40〜50 days. This investigation was supported by Grant in Aid for Development Scientific Research provided by the Ministry of Education (1956).
公益社団法人日本薬学会の論文
1958-02-20