Mechanistic Studies on the Biomimetic Reduction of Tetrahydroxynaphthalene, a Key Intermediate in Melanin Biosynthesis
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概要
- 論文の詳細を見る
1, 3, 6, 8-Tetrahydroxynaphthalene(T4HN)is an aromatic polyketide, serving as a general precursor of fungal melanin. Melanin biosynthesis involves two consecutive deoxygenations of T4HN, consisting of the reduction of a phenolic carbon followed by dehydration. The first reduction to produce scytalone was studied in a biomimetic reduction with sodium borohydride. The reduction required a strong alkaline condition, leading to the tautomerization of T4HN to a reactive species whose structure was clarified by NMR spectroscopy.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
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Ebizuka Yutaka
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Sankawa Ushio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Ebizuka Yutaka
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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ICHINOSE Koji
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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