Cell Death Mode Switch from Necrosis to Apoptosis in Brain

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概要

• 論文の詳細を見る

• In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell death induced by ischemic stress should eventually be terminated. Thus, the authors propose the hypothesis that the cell death mode switch in the event of brain ischemia is an in vivo self-protective mechanism. The authors attempt to overview the current understanding of the molecular mechanisms of necrosis and apoptosis in relation to the ATP hypothesis, and also introduce novel mechanisms for an in vitro cell death mode switch.

• 公益社団法人日本薬学会の論文
• 2004-07-01

著者

• FUJITA Reiko

  Tohoku Pharmaceutical University

• Fujita R

  Tohoku Pharmaceutical University

• Fujita R

  Department Of Chemistry School Of Liberal Arts And Sciences Iwate Medical University

• Ueda Hiroshi

  Division of Environmental Science Creation, Graduate School of Environmental Science, Hokkaido Unive

• FUJITA Ryousuke

  Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedic

• Ueda Hiroshi

  Division Of Environmental Science Creation Graduate School Of Environmental Science Hokkaido Univers

• Ueda Hiroshi

  Division Of Molecular Pharmacology And Neuroscience Nagasaki University Graduate School Of Biomedica

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