Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury–Induced Neuropathic Pain Models
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概要
- 論文の詳細を見る
Botulinum toxin type A is a unique candidate for inhibition of pain transmission. In the present study we attempted to see the beneficial actions of A2 neurotoxin (NTX), an active subunit of botulinum toxin type A. Intraplantar injection of A2 NTX significantly suppressed mechanical allodynia and hypersensitivities to A-fiber stimuli in the diabetic neuropathic pain model. Spinal application of A2 NTX also showed a potent suppression of thermal hyperalgesia and mechanical allodynia in the spinal cord injury–induced neuropathic pain model. A2 NTX seems to be a long-lasting treatment for diabetic and spinal cord injury–induced neuropathic pain.
- 公益社団法人 日本薬理学会の論文
著者
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Ueda Hiroshi
Division Of Environmental Science Creation Graduate School Of Environmental Science Hokkaido Univers
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GOTO Yoshitaka
The Chemo-Sero-Therapeutic Research Institute
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NAKAHIRA Shinji
The Chemo-Sero-Therapeutic Research Institute
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Sekino Yuki
Division Of Molecular Pharmacology And Neuroscience Nagasaki University Graduate School Of Biomedical Sciences
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MA Lin
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences
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NAGAI Jun
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences
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Ma Lin
Division Of Molecular Pharmacology And Neuroscience Nagasaki University Graduate School Of Biomedical Sciences
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Goto Yoshitaka
The Chemo-sero Therapeutic Research Institute
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Nagai Jun
Division Of Molecular Pharmacology And Neuroscience Nagasaki University Graduate School Of Biomedical Sciences
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Nakahira Shinji
The Chemo-sero Therapeutic Research Institute
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Goto Yoshitaka
The Chemo-Sero Therapeutic Research Institute, Japan
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- Foreword
- Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury-Induced Neuropathic Pain Models
- Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury–Induced Neuropathic Pain Models