Cyclization of 1-Benzyl-1,2-dihydro-2-(substituted methylene)quinolines to Pyrrolo [1,2-a] quinoline Derivatives
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概要
- 論文の詳細を見る
1-Alkyl-2-alkylthioquinolinium salts were prepared from 1-alkyl-2 (1H)-quinolones via 1-alkyl-2 (1H)-thio-quinolones in two steps. Under mild conditions, the reaction of 1-alkyl-2-alkylthioquinolinium iodides with active methyl-ene compounds in the presence of sodium hydride afforded 1-alkyl-1, 2-dihydro-2-(substituted methylene) quinolines in good yields. The cyclization of 1-benzylquinolines using acetic anhydride produced the corre-sponding pyrrolo [1, 2-a] quinoline derivatives.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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FUJITA Reiko
Tohoku Pharmaceutical University
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TOMISAWA Hiroshi
Tohoku Pharmaceutical University
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Fujita R
Tohoku Pharmaceutical University
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Fujita R
Department Of Chemistry School Of Liberal Arts And Sciences Iwate Medical University
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Hoshino M
Tohoku Pharmaceutical University
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HOSHINO Masato
Tohoku Pharmaceutical University
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Tomisawa H
Tohoku Pharmaceutical University
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