Novel Diels-Alder Reaction of 4-Nitro-1(2H)-isoquinolones
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概要
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A novel Diels-Alder (DA) reaction with 4-nitro-1(2H)-isoquinolones acting as the dienophile afforded 5(6H)-phenanthridone derivatives. The DA reaction of 4-nitro-1(2H)-isoquinolone with 1-methoxy-1, 3-butadiene gave biologically active 5(6H)-phenanthridone possessing in a high yield. Regioselectivity of 4-nitro-1(2H)-iso-quinolones with 1-methoxy-3-silyloxy-1, 3-butadiene was calculated using molecular orbital (MO) calculations.
- 公益社団法人日本薬学会の論文
- 2006-02-01
著者
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FUJITA Reiko
Tohoku Pharmaceutical University
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Fujita R
Tohoku Pharmaceutical University
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Fujita R
Department Of Chemistry School Of Liberal Arts And Sciences Iwate Medical University
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MATSUZAKI Hisao
Tohoku Pharmaceutical University
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WAKAYANAGI Sota
Tohoku Pharmaceutical University
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WAKAMATSU Hideaki
Tohoku Pharmaceutical University
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Matsuzaki H
Tohoku Pharmaceutical University
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