モルモット骨髄による誘導効果の時間関係 : IV. 中胚葉誘導体による神経組織の分化

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As a part of serial reports of the study on the time course of mesodermal induction in the primary induction system, this report dealt with the neural induction evoked by a "mesodermal" inductor. As in the previous reports, isolated presumptive ectoderm (E) of the newt (Triturus pyrrhogaster) embryo (St. 12, by Okada and Ichikawa, 1947) was used as a reactor, and extracts of the guinea pig liver (L) and bone-marrow (BM) were used as a neural and a mesodermal inductor, respectively. 1) In limited duration up to 12 hours of contact with L, a little but solely neural induction was evoked in E. Contrary to the L, the BM had strong activity to produce mesodermal induction with a little neural one. This activity of BM was observed on E which had been kept free from any inductive stimulus for 7 hours after the isolation from embryo. 2) Successive contact with BM following short contact with L produced remarkable increase of neural differentiation in E. This led to the conclusion that the some inductive information of L had been transfered to E in early time of contact (at least within 3 hours) which, by L itself, was too short to realize a neural induction in E. 3) Mesodermal induction evoked in E by BM stimulus folloing several hours' contact with L was not stronger than that evoked in E which had been cultured alone for the corresponding time; the predecessor stimulus of L deducted the effects of the successor one of BM.
社団法人日本動物学会の論文
1975-03-25

モルモット骨髄による誘導効果の時間関係 : IV. 中胚葉誘導体による神経組織の分化

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