モルモット骨髄による誘導効果の時間関係 : III.前脳誘導体による中胚葉組織の分化

概要

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(1)By short term (1/2 and 1 hour) contact with the extract of guinea pig bone-marrow (BM), the extodermal pieces from the gastrulae of Triturus pyrrhogaster were hardly able to differentiate into either neural or mesodermal structures. (2)By successive application of guinea pig liver extract (L) to the ectodermal pieces treated for 1/2 or 1 hour with BM, the ectodermal pieces differentiated into neural as well as mesodermal structures (spinocaudal nature). (3)By application of egg albumen as a substitute for L, the response of the ectoderm to BM was not amplified in a similar fashion as observed with L. (4)The ectoderm precultured in saline without BM extract included for 1/2 or 1 hour responded to L by pure neural differentiation (archencephalic nature). (5)Thus, it may be assumed that the ectodermal pieces would be impregnated with some information for mesodermal differentiation by a short contact with BM and realized by subsequent L stimulus.
社団法人日本動物学会の論文
1972-06-25