免疫疾患のアフェレシス療法

概要

論文の詳細を見る
Blood purification for acute immune diseases is necessary in the cases of fulminant onset, acute on chronic phase, stopping steroids and quick removal of antibodies. The choice of blood purification method is important. In patients with serious SLE, multiple myeloma or thrombotic thrombocytopenic purpura, plasma exchange is essential for initial treatment to remove antibodies, immune complexes, cytokines and some mediators. In addition to plasma exchange, hemodialysis is useful to regulate body fluids. After recovery from serious conditions, double-filtration plasmapheresis or cryofiltration is applied for maintenance of the recovered condition. In patients with mild rheumatoid arthritis, SLE, aortitis syndrome or renal transplantation, double-filtration plasmapheresis, cryofiltration and immunoadsorption is applied for the removal of antibodies and EDA(+) fibronectin. In inflammatory bowel diseases, such as Crohn disease and ulcerative colitis, cytapheresis is chosen. We often apply cryofiltration. Its mechanism consists of two principles : adsorption utilizing heparin and mechanical filtration. Sixty patients with acute immune diseases were treated with blood purification processes. The effectiveness of apheressis is influenced by the seriousness of the disease. However, as it can certainly reduce immune complexes and antibodies, and can reduce steroid dose requirements, it should be applied more often.
日本アフェレシス学会の論文
1999-02-28

免疫疾患のアフェレシス療法

スポンサーリンク

概要

著者

関連論文

スポンサーリンク