リンパ球除去は炎症性腸疾患に有効か : 繊維を用いた白血球系細胞除去療法

概要

論文の詳細を見る
Leukocytapheresis (LCAP) is widely used for the treatment of immunological diseases. In this study, we applied a new treatment of LCAP by using a nonwoven polyester fiber filter. The filtratlon method was a blood collection bag system. That is, the blood from an artery was led to the filter without using a rotary pump, and the filtrated blood was returned to a superficial vein. From 30 to 68% of leukocyte subsets were removed. Cytokines were well modulated in the filter. Eleven or 12 patients with ulcerative colitis (UC) were induced to remission. Four patients with Crohn's disease (CD) showed improvement. LCAP, using a nonwoven polyester fiber filter, was very efficient for treating the patients with IBD. It should also become a very useful treatment for immunological diseases and extracorporeal immunomodulation.
日本アフェレシス学会の論文
2000-02-29